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TLR9
Description:
Toll-like receptor 9, an innate immune receptor that recognizes DNA containing unmethylated CpG motifs and helps initiate immune responses.
Primary topic:
Immune Response and Inflammation (30%)
Related topics:
Immune Response and Inflammation (30%),
Immunotherapy and Immune Responses (7%)
OpenAlex ID:
keywords/tlr9
A Toll-like receptor recognizes bacterial DNA
2000
·
Hiroaki Hemmi
, Osamu Takeuchi
, et al.
·
Nature
·
6,488
Circulating mitochondrial DAMPs cause inflammatory responses to injury
2010
·
Qin Zhang
, Mustafa Raoof
, et al.
·
Nature
·
3,804
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
2006
·
Marc Veldhoen
, Richard J. Hocking
, et al.
·
Immunity
·
3,603
PDF
CpG Motifs in Bacterial DNA and Their Immune Effects
2002
·
Arthur M. Krieg
·
Annual Review of Immunology
·
2,575
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012
·
Jorge Henao-Mejia
, Eran Elinav
, et al.
·
Nature
·
2,435
IRF-7 is the master regulator of type-I interferon-dependent immune responses
2005
·
Kenya Honda
, Hideyuki Yanai
, et al.
·
Nature
·
2,247
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
2001
·
Norimitsu Kadowaki
, Stephen Ho
, et al.
·
The Journal of Experimental Medicine
·
1,966
PDF
Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides
2002
·
Veit Hornung
, Simon Rothenfusser
, et al.
·
The Journal of Immunology
·
1,936
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
2007
·
Roberto Lande
, Josh Gregorio
, et al.
·
Nature
·
1,909
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002
·
Elizabeth A. Leadbetter
, Ian R. Rifkin
, et al.
·
Nature
·
1,900
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
2004
·
Yong-Jun Liu
·
Annual Review of Immunology
·
1,625
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
2001
·
Stefan Bauer
, Carsten J. Kirschning
, et al.
·
Proceedings of the National Academy of Sciences
·
1,533
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
2011
·
Gina S. Garcia-Romo
, Simone Caielli
, et al.
·
Science Translational Medicine
·
1,383
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
2007
·
Jane Tian
, Ana Maria Avalos
, et al.
·
Nature Immunology
·
1,370
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
2004
·
Eicke Latz
, Annett Schoenemeyer
, et al.
·
Nature Immunology
·
1,361
Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus
2011
·
Roberto Lande
, Dipyaman Ganguly
, et al.
·
Science Translational Medicine
·
1,305
Therapeutic potential of Toll-like receptor 9 activation
2006
·
Arthur M. Krieg
·
Nature Reviews Drug Discovery
·
1,248
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
2003
·
Jennifer Lund
, Ayuko Sato
, et al.
·
The Journal of Experimental Medicine
·
1,198
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
2012
·
Takafumi Oka
, Shungo Hikoso
, et al.
·
Nature
·
1,197
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
2008
·
Michel Gilliet
, Wei Cao
, et al.
·
Nature reviews. Immunology
·
1,187
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
·
Giorgio Napolitani
, Andrea Rinaldi
, et al.
·
Nature Immunology
·
1,157
Recognition of pathogen-associated molecular patterns by TLR family
2003
·
Shizuo Akira
, Hiroaki Hemmi
·
Immunology Letters
·
1,150
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
2006
·
Sean R. Christensen
, Jonathan Shupe
, et al.
·
Immunity
·
1,089
PDF
Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3
2005
·
Michael Martin
, Kunal Rehani
, et al.
·
Nature Immunology
·
1,081
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
2004
·
Taro Kawai
, Shintaro Sato
, et al.
·
Nature Immunology
·
1,034
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Works count:
10,800
Citation count:
380,900
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