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Keyword

TMEM97

Description: A human protein-coding gene that encodes transmembrane protein 97, also known as the sigma-2 receptor.
Wikidata ID: wiki/Q18038800
OpenAlex ID: keywords/tmem97
Identification of the gene that codes for the σ 2 receptor
2017 · Assaf Alon, Hayden R. Schmidt, et al. · Proceedings of the National Academy of Sciences · 268
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TMEM Proteins in Cancer: A Review
2018 · Kathleen Schmit, Carine Michiels · Frontiers in Pharmacology · 237
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Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening
2009 · Fabian Bartz, Luise Kern, et al. · Cell Metabolism · 195
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Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex
2018 · Aladdin Riad, Chenbo Zeng, et al. · Scientific Reports · 140
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Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
2017 · James J. Sahn, Galo L. Mejia, et al. · ACS Chemical Neuroscience · 94
Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells
2016 · Darius Ebrahimi-Fakhari, Lara Wahlster, et al. · Human Molecular Genetics · 94
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The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates
2020 · Aladdin Riad, Zsofia Lengyel-Zhand, et al. · Molecular Neurobiology · 77
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Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes
2019 · Halley M. Oyer, Christina M. Sanders, et al. · Frontiers in Pharmacology · 61
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Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury
2018 · Edwin Vázquez-Rosa, Michael R. Watson, et al. · ACS Chemical Neuroscience · 60
The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer
2020 · Chenbo Zeng, Aladdin Riad, et al. · Cancers · 56
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A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
2018 · João Ramalho-Carvalho, Céline S. Gonçalves, et al. · Clinical Epigenetics · 56
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A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes
2021 · Yu-Shiuan Cheng, Tianyi Zhang, et al. · Nature Chemical Biology · 54
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Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer
2007 · Cathy B Wilcox, Grace O Feddes, et al. · BMC Cancer · 51
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Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases
2023 · Britney N. Lizama, Jennifer Kahle, et al. · International Journal of Molecular Sciences · 49
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TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death
2019 · Chenbo Zeng, Chi-Chang Weng, et al. · Cell Death Discovery · 49
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Sigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis
2020 · Kai Yang, Cheng Zeng, et al. · Molecules · 45
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Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression
2010 · Oleg V Grinchuk, Efthimios Motakis, et al. · BMC Genomics · 44
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RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells
2015 · Guanzhong Qiu, Wei Sun, et al. · Tumor Biology · 43
Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors
2018 · Luisa L. Scott, James J. Sahn, et al. · Neuropsychopharmacology · 40
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Down-Regulated MAC30 Expression Inhibits Proliferation and Mobility of Human Gastric Cancer Cells
2014 · Xiao-Yan Xu, Li-Juan Zhang, et al. · Cellular Physiology and Biochemistry · 40
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NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines
2020 · Carlos Cantonero, Pedro Javier Camello, et al. · Cancers · 38
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The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice
2020 · Sema G. Quadir, Sean M. Tanino, et al. · Neuropharmacology · 33
A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands
2018 · Giuseppe Floresta, Emanuele Amata, et al. · Marine Drugs · 33
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High-Throughput Gene Expression Profiles to Define Drug Similarity and Predict Compound Activity
2018 · Hans De Wolf, Laure Cougnaud, et al. · Assay and Drug Development Technologies · 32
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Identification of stable reference genes for quantitative PCR in koalas
2018 · N. Sarker, J. Fabijan, et al. · Scientific Reports · 32
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Works count: 173
Citation count: 2,696
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