Keyword

TORC1

Description: A target of rapamycin protein complex that integrates cellular signals to regulate growth, metabolism, gene expression, and other processes.

Primary topic: PI3K/AKT/mTOR signaling in cancer (30%)

Wikidata ID: wiki/Q14876060

OpenAlex ID: keywords/torc1

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 · Estela Jacinto, Robbie Loewith, et al. · Nature Cell Biology · 2,114

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

2006 · Estela Jacinto, Valeria Facchinetti, et al. · Cell · 1,410

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Regulation of TORC1 by Rag GTPases in nutrient response

2008 · Eunjung Kim, Pankuri Goraksha-Hicks, et al. · Nature Cell Biology · 1,348

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 · Greg M. Delgoffe, Thomas P. Kole, et al. · Immunity · 1,286

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

2015 · Remi-Martin Laberge, Yu Sun, et al. · Nature Cell Biology · 1,156

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

2010 · Ivana Bjedov, Janne M. Toivonen, et al. · Cell Metabolism · 1,057

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The Two TORCs and Akt

2007 · Prashanth T. Bhaskar, Nissim Hay · Developmental Cell · 798

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Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae

2007 · Jörg Urban, Alexandre Soulard, et al. · Molecular Cell · 797

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Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

2009 · Anne Ulrike Trendelenburg, Angelika Meyer, et al. · American Journal of Physiology-Cell Physiology · 790

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

2010 · Ashton Breitkreutz, Hyungwon Choi, et al. · Science · 683

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

2012 · Stacey Robida-Stubbs, Kira Glover-Cutter, et al. · Cell Metabolism · 648

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The expanding TOR signaling network

2005 · Dietmar E Martin, Michael N Hall · Current Opinion in Cell Biology · 495

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

2009 · Yoshiaki Kamada, Ken-ichi Yoshino, et al. · Molecular and Cellular Biology · 492

mTOR in aging, metabolism, and cancer

2013 · Marion Cornu, Verena Albert, et al. · Current Opinion in Genetics & Development · 449

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

2009 · Matteo Binda, Marie-Pierre Péli-Gulli, et al. · Molecular Cell · 437

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Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

2014 · Constantinos Demetriades, Nikolaos Doumpas, et al. · Cell · 420

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Mitochondrial Diseases of the Brain

2013 · Rajnish K. Chaturvedi, M. Flint Beal · Free Radical Biology and Medicine · 414

Amino acid regulation of TOR complex 1

2008 · Joseph Avruch, Xiaomeng Long, et al. · American Journal of Physiology-Endocrinology and Metabolism · 382

Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway

2011 · Cui, Libin, Supinski, Andrea, et al. · PubMed Central · 367

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

2003 · Vadim Iourgenko, Wenjun Zhang, et al. · Proceedings of the National Academy of Sciences · 367

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

2012 · Grégory Bonfils, Malika Jaquenoud, et al. · Molecular Cell · 340

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Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

2009 · Alexandre Huber, Bernd Bodenmiller, et al. · Genes & Development · 334

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

2014 · David J. Roberts, Valerie P. Tan-Sah, et al. · Molecular Cell · 330

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Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

2011 · Yong Pan, Elizabeth A. Schroeder, et al. · Cell Metabolism · 315

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Nutrient regulates Tor1 nuclear localization and association with rDNA promoter

2006 · Hong Li, Chi Kwan Tsang, et al. · Nature · 303

Works count: 1,559

Citation count: 52,210