Keyword

toxin B

Description: A major cytotoxin produced by Clostridioides difficile, studied for its role in intestinal disease and as a target of diagnosis and vaccination.

Primary topic: Clostridium difficile and Clostridium perfringens research (88%)

OpenAlex ID: keywords/toxin-b

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

2005 · Michel Warny, Jacques Pepin, et al. · The Lancet · 1,430

Asymptomatic Carriage ofClostridium difficileand Serum Levels of IgG Antibody against Toxin A

2000 · Lorraine Kyne, Michel Warny, et al. · New England Journal of Medicine · 935

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Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

2017 · Mark H. Wilcox, Dale N. Gerding, et al. · New England Journal of Medicine · 858

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The role of toxin A and toxin B in Clostridium difficile infection

2010 · Sarah A. Kuehne, Stephen T. Cartman, et al. · Nature · 855

Clostridium difficile infection

2016 · Wiep Klaas Smits, Dena Lyras, et al. · Nature Reviews Disease Primers · 854

Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea

2001 · Lorraine Kyne, Michel Warny, et al. · The Lancet · 804

Treatment with Monoclonal Antibodies against Clostridium difficile Toxins

2010 · Israel Lowy, Deborah C. Molrine, et al. · New England Journal of Medicine · 746

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Toxin B is essential for virulence of Clostridium difficile

2009 · Dena Lyras, Jennifer R. O’Connor, et al. · Nature · 745

Emergence ofClostridium difficileInfection Due to a New Hypervirulent Strain, Polymerase Chain Reaction Ribotype 078

2008 · Abraham Goorhuis, Dennis Bakker, et al. · Clinical Infectious Diseases · 637

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Clostridium difficile: its disease and toxins

1988 · D M Lyerly, H C Krivan, et al. · Clinical Microbiology Reviews · 576

Clostridium difficile colitis: pathogenesis and host defence

2016 · Michael C. Abt, Peter T. McKenney, et al. · Nature Reviews Microbiology · 551

The Role of Local Actin Instability in Axon Formation

1999 · Frank Bradke, Carlos G. Dotti · Science · 533

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 · Wendy S Garrett, Li-Mei Chen, et al. · Cell · 452

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Clostridium difficile Infection

1998 · Ciarán P. Kelly, J. Thomas LaMont · Annual Review of Medicine · 420

European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection (CDI)

2009 · M.J.T. Crobach, O.M. Dekkers, et al. · Clinical Microbiology and Infection · 413

Saccharomyces boulardii Protease Inhibits the Effects of Clostridium difficile Toxins A and B in Human Colonic Mucosa

1999 · Ignazio Castagliuolo, Martin F. Riegler, et al. · Infection and Immunity · 408

Effects of Clostridium difficile toxins given intragastrically to animals

1985 · D M Lyerly, K E Saum, et al. · Infection and Immunity · 400

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Purification and characterization of toxins A and B of Clostridium difficile

1982 · N M Sullivan, S Pellett, et al. · Infection and Immunity · 368

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Identification of Toxin A-Negative, Toxin B-Positive Clostridium difficile by PCR

1998 · Haru Kato, Naoki Kato, et al. · Journal of Clinical Microbiology · 357

The role of toxins in Clostridium difficile infection

2017 · Ramyavardhanee Chandrasekaran, D. Borden Lacy · FEMS Microbiology Reviews · 353

Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.

1995 · M Riegler, R Sedivy, et al. · Journal of Clinical Investigation · 340

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Clostridium difficile--Associated diarrhea: A review.

2001 · E Mylonakis, E T Ryan, et al. · PubMed · 339

Multiplex PCR Targetingtpi(Triose Phosphate Isomerase),tcdA(Toxin A), andtcdB(Toxin B) Genes for Toxigenic Culture ofClostridium difficile

2004 · Ludovic Lemee, Anne Dhalluin, et al. · Journal of Clinical Microbiology · 337

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

2014 · Jhansi L. Leslie, Sha Huang, et al. · Infection and Immunity · 330

Definition of the single integration site of the pathogenicity locus in Clostridium difficile

1996 · Veit Braun, Thomas Hundsberger, et al. · Gene · 330

Works count: 1,960

Citation count: 56,420