Keyword

TPC2

Description: TPC2 is a two-pore ion channel protein encoded by TPCN2 that mediates calcium and other ion transport in endolysosomal membranes.

Primary topic: Calcium signaling and nucleotide metabolism (66%)

Wikidata ID: wiki/Q18053389

OpenAlex ID: keywords/tpc2

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

2020 · Xiuyuan Ou, Yan Liu, et al. · Nature Communications · 3,091

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NAADP mobilizes calcium from acidic organelles through two-pore channels

2009 · Peter J. Calcraft, Margarida Ruas, et al. · Nature · 758

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TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

2012 · Xiang Wang, Xiaoli Zhang, et al. · Cell · 530

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

2009 · Eugen Brailoiu, Dev Churamani, et al. · The Journal of Cell Biology · 401

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mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

2013 · Chunlei Cang, Yandong Zhou, et al. · Cell · 363

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Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

2010 · Margarida Ruas, Katja Rietdorf, et al. · Current Biology · 249

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TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

2010 · Samantha J. Pitt, Tim M. Funnell, et al. · Journal of Biological Chemistry · 221

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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

2014 · Christian Grimm, Lesca M. Holdt, et al. · Nature Communications · 201

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Convergent regulation of the lysosomal two‐pore channel‐2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

2014 · Archana Jha, Malini Ahuja, et al. · The EMBO Journal · 175

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Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by two-pore channel 2 inhibition

2014 · Leanne N. Hockey, Bethan S. Kilpatrick, et al. · Journal of Cell Science · 174

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+ Signals

2010 · Eugen Brailoiu, Taufiq Rahman, et al. · Journal of Biological Chemistry · 169

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Function and dysfunction of two-pore channels

2015 · Sandip Patel · Science Signaling · 164

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

2020 · Susanne Gerndt, Cheng-Chang Chen, et al. · eLife · 162

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca 2+ signaling

2014 · Annarita Favia, Marianna Desideri, et al. · Proceedings of the National Academy of Sciences · 161

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells*

2011 · Yaping Lin-Moshier, Timothy F. Walseth, et al. · Journal of Biological Chemistry · 161

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Expression of Ca2+‐permeable two‐pore channels rescues NAADP signalling in TPC‐deficient cells

2015 · Margarida Ruas, Lianne C Davis, et al. · The EMBO Journal · 157

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TPC2 controls pigmentation by regulating melanosome pH and size

2016 · Andrea L. Ambrosio, Judith A. Boyle, et al. · Proceedings of the National Academy of Sciences · 134

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Calcium signaling via two-pore channels: local or global, that is the question

2009 · Michael X. Zhu, Jianjie Ma, et al. · American Journal of Physiology-Cell Physiology · 132

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

2017 · Ong Nam Phuong Nguyen, Christian Grimm, et al. · Cancer Research · 127

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

2014 · Yaping Lin-Moshier, Michael V. Keebler, et al. · Proceedings of the National Academy of Sciences · 124

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Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

2020 · Nicola Clementi, Carolina Scagnolari, et al. · Pharmacological Research · 123

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Structural mechanisms of phospholipid activation of the human TPC2 channel

2019 · Ji She, Weizhong Zeng, et al. · eLife · 122

The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin

2017 · Qi Cao, Yiming Yang, et al. · Journal of Biological Chemistry · 122

Tuning the ion selectivity of two-pore channels

2017 · Jiangtao Guo, Weizhong Zeng, et al. · Proceedings of the National Academy of Sciences · 120

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NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

2018 · Gihan S. Gunaratne, Yang Yang, et al. · Cell Calcium · 118

Works count: 418

Citation count: 13,080