Keyword

TRAF2

Description: TRAF2 is a human protein-coding gene whose protein product participates in tumor necrosis factor receptor signaling and regulation of immune and cell-death pathways.

Primary topic: NF-κB Signaling Pathways (33%)

Wikidata ID: wiki/Q14914361

OpenAlex ID: keywords/traf2

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 · Fumihiko Urano, XiaoZhong Wang, et al. · Science · 2,991

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 · Olivier Micheau, Jürg Tschopp · Cell · 2,728

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NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 · Cun-Yu Wang, Marty W. Mayo, et al. · Science · 2,712

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TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 · Hailing Hsu, Hong-Bing Shu, et al. · Cell · 1,998

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Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 · Zheng-gang Liu, Hailing Hsu, et al. · Cell · 1,938

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1997 · Nikolai L. Malinin, Mark P. Boldin, et al. · Nature · 1,280

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 · Mike Rothe, Ming-Gui Pan, et al. · Cell · 1,249

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 · Mike Rothe, Suzy C. Wong, et al. · Cell · 1,054

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 · Mike Rothe, Vidya Sarma, et al. · Science · 1,051

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

2009 · Mara Compagno, Wei Keat Lim, et al. · Nature · 1,038

The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

2003 · Andrew Kovalenko, Christine Chable-Bessia, et al. · Nature · 1,016

Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

2007 · Jonathan J. Keats, Rafael Fonseca, et al. · Cancer Cell · 981

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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 · George Mosialos, Mark Birkenbacht, et al. · Cell · 980

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CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

2003 · Eirini Trompouki, Eudoxia Hatzivassiliou, et al. · Nature · 963

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 · Thijn R. Brummelkamp, Sebastian M. B. Nijman, et al. · Nature · 952

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 · Takunari Yoneda, Kazunori Imaizumi, et al. · Journal of Biological Chemistry · 865

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 · Brian R. Wong, Régis Josien, et al. · The Journal of Experimental Medicine · 853

NF-κB Signals Induce the Expression of c-FLIP

2001 · Olivier Micheau, Susanne Lens, et al. · Molecular and Cellular Biology · 813

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 · Wen-Chen Yeh, Arda Shahinian, et al. · Immunity · 798

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Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

2009 · Tobias L. Haas, Christoph H. Emmerich, et al. · Molecular Cell · 776

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Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression

2006 · Ping Hu, Zhang Han, et al. · Molecular and Cellular Biology · 754

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

2010 · Sergio E. Alvarez, Kuzhuvelil B. Harikumar, et al. · Nature · 753

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The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 · Lijun Sun, Li Deng, et al. · Molecular Cell · 699

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Distinct molecular mechanism for initiating TRAF6 signalling

2002 · Hong Ye, Joseph R. Arron, et al. · Nature · 662

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 · Arul M. Chinnaiyan, Karen O'Rourke, et al. · Science · 654

Works count: 2,613

Citation count: 142,800