Keyword

TRF2

Description: TRF2 is a shelterin protein that binds telomeric DNA and helps regulate telomere structure, length, and stability in human cells.

Primary topic: Telomeres, Telomerase, and Senescence (65%)

Wikidata ID: wiki/Q18031949

OpenAlex ID: keywords/trf2

Shelterin: the protein complex that shapes and safeguards human telomeres

2005 · Titia de Lange · Genes & Development · 3,055

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Mammalian Telomeres End in a Large Duplex Loop

1999 · Jack D Griffith, Laurey Comeau, et al. · Cell · 2,449

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TRF2 Protects Human Telomeres from End-to-End Fusions

1998 · Bas van Steensel, Agata Smogorzewska, et al. · Cell · 1,709

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DNA Damage Foci at Dysfunctional Telomeres

2003 · Hiroyuki Takai, Agata Smogorzewska, et al. · Current Biology · 1,408

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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 · Jan Karlseder, Dominique Broccoli, et al. · Science · 1,086

Protection of mammalian telomeres

2002 · Titia de Lange · Oncogene · 942

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

1997 · Dominique Broccoli, Agata Smogorzewska, et al. · Nature Genetics · 925

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

2007 · Eros Lazzerini Denchi, Titia de Lange · Nature · 880

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

2012 · Marzia Fumagalli, Francesca Rossiello, et al. · Nature Cell Biology · 847

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 · Jan Karlseder, Agata Smogorzewska, et al. · Science · 795

Control of Human Telomere Length by TRF1 and TRF2

2000 · Agata Smogorzewska, Bas van Steensel, et al. · Molecular and Cellular Biology · 767

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 · T R Yeager, A A Neumann, et al. · PubMed · 678

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

2016 · Siyuan Zheng, Andrew D. Cherniack, et al. · Cancer Cell · 658

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

2005 · Giulia B. Celli, Titia de Lange · Nature Cell Biology · 623

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

2000 · Xu-Dong Zhu, Bernhard Küster, et al. · Nature Genetics · 606

Removal of Shelterin Reveals the Telomere End-Protection Problem

2012 · Agnel Sfeir, Titia de Lange · Science · 583

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

2008 · Nadya Dimitrova, Yi-Chun M. Chen, et al. · Nature · 583

Identification of Human Rap1

2000 · Bibo Li, Stephanie Oestreich, et al. · Cell · 583

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TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

2009 · Zhong Deng, Julie Norseen, et al. · Molecular Cell · 549

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T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang

2001 · Rachel M. Stansel, Titia de Lange, et al. · The EMBO Journal · 535

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Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres

2004 · Richard C. Wang, Agata Smogorzewska, et al. · Cell · 512

Telomeric localization of TRF2, a novel human telobox protein

1997 · Thomas Bilaud, Christine Brun, et al. · Nature Genetics · 506

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

2013 · Ylli Doksani, John Y. Wu, et al. · Cell · 493

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Different telomere damage signaling pathways in human and mouse cells

2002 · Agata Smogorzewska, Titia de Lange · The EMBO Journal · 483

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Computational analysis of core promoters in the Drosophila genome

2002 · Uwe Ohler, Guo-chun Liao, et al. · Genome biology · 454

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Works count: 1,897

Citation count: 72,150