Keyword

triptolide

Description: A biologically active diterpenoid compound investigated in pharmacology for its effects on inflammation, cancer cells, and other disease processes.

Primary topic: Natural Compounds in Disease Treatment (52%)

Wikidata ID: wiki/Q906351

OpenAlex ID: keywords/triptolide

TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

2004 · Thomas Y. Ma, Gary K. Iwamoto, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 909

Broad targeting of resistance to apoptosis in cancer

2015 · Ramzi M. Mohammad, Irfana Muqbil, et al. · Seminars in Cancer Biology · 876

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Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

2007 · Timothy W. Corson, Craig M. Crews · Cell · 654

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Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

2014 · Iris Jonkers, Hojoong Kwak, et al. · eLife · 579

Inhibiting eukaryotic transcription. Which compound to choose? How to evaluate its activity?

2011 · Olivier Bensaude · Transcription · 574

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

2019 · Hua Luo, Chi Teng Vong, et al. · Chinese Medicine · 564

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XPB, a subunit of TFIIH, is a target of the natural product triptolide

2011 · Denis V Titov, Benjamin Gilman, et al. · Nature Chemical Biology · 509

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

1972 · S. Morris Kupchan, William A. Court, et al. · Journal of the American Chemical Society · 501

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

2007 · Anita M. Brinker, Jun Ma, et al. · Phytochemistry · 415

Anti-cancer natural products isolated from chinese medicinal herbs

2011 · Wen Tan, Jinjian Lu, et al. · Chinese Medicine · 398

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Triptolide: Progress on research in pharmacodynamics and toxicology

2014 · Xiao-Jiaoyang Li, Zhen-Zhou Jiang, et al. · Journal of Ethnopharmacology · 378

Triptolide and its expanding multiple pharmacological functions

2011 · Qiuyan Liu · International Immunopharmacology · 346

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

2016 · Prasad R. Dandawate, Dharmalingam Subramaniam, et al. · Seminars in Cancer Biology · 327

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

2018 · Shao-Ru Chen, Yan Dai, et al. · Frontiers in Pharmacology · 326

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Targeting apoptosis pathways in cancer by Chinese medicine

2010 · Min Li-Weber · Cancer Letters · 318

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

2012 · Zhao-Li Zhou, Ya-Xi Yang, et al. · Natural Product Reports · 312

Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

2003 · Daoming Qiu, Peter N. Kao · Drugs in R&D · 312

Triptolide and Its Derivatives as Cancer Therapies

2019 · Pawan Noel, Daniel D. Von Hoff, et al. · Trends in Pharmacological Sciences · 311

A study of microemulsion systems for transdermal delivery of triptolide

2004 · Huabing Chen, Xueling Chang, et al. · Journal of Controlled Release · 310

Triptolide Induces Pancreatic Cancer Cell Death via Inhibition of Heat Shock Protein 70

2007 · Phoebe A. Phillips, Vikas Dudeja, et al. · Cancer Research · 304

Solid lipid nanoparticle and microemulsion for topical delivery of triptolide

2003 · Z Mei · European Journal of Pharmaceutics and Biopharmaceutics · 303

Triptolide, A Novel Immunosuppressive and Anti-Inflammatory Agent Purified from a Chinese Herb Tripterygium Wilfordii Hook F

2001 · Benny J. Chen · Leukemia & lymphoma/Leukemia and lymphoma · 301

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

2015 · Hala Gali-Muhtasib, Raed Hmadi, et al. · APOPTOSIS · 293

Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages

2002 · Peili Chen, Ji Li, et al. · The Journal of Immunology · 286

Toxicity of triptolide and the molecular mechanisms involved

2017 · Chen Xi, Shaojun Peng, et al. · Biomedicine & Pharmacotherapy · 280

Works count: 3,705

Citation count: 71,140