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Keyword

triptonide

Description: Triptonide is a diterpenoid natural product investigated for biological activity and as a potential therapeutic compound.
Wikidata ID: wiki/Q72514890
OpenAlex ID: keywords/triptonide
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes
2023 · Jing Song, Guan-Nan He, et al. · Biomedicine & Pharmacotherapy · 163
Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine
2018 · Yiqun Li, Huiting Cao, et al. · Chinese Medicine · 156
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
2021 · Zongliang Chang, Weibing Qin, et al. · Nature Communications · 106
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Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity
2015 · Xin-Xiu Li, Fu-Ying Du, et al. · Journal of Ethnopharmacology · 100
Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling
2018 · Shu-sheng Wang, Yan Lv, et al. · Cancer Letters · 91
Enantioselective Total Synthesis of (−)-Triptolide, (−)-Triptonide, (+)-Triptophenolide, and (+)-Triptoquinonide
2000 · Dan Yang, Xiang-Yang Ye, et al. · The Journal of Organic Chemistry · 85
Lanthanide Triflates Catalyze Mn(III)-Based Oxidative Radical Cyclization Reactions. Enantioselective Synthesis of (−)-Triptolide, (−)-Triptonide, and (+)-Triptophenolide
1999 · Dan Yang, Xiang-Yang Ye, et al. · Journal of the American Chemical Society · 79
Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking
2023 · Jia-Chen Ge, Qi Qian, et al. · Phytomedicine · 73
Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide
2022 · Nikolaj Lervad Hansen, Louise Kjaerulff, et al. · Nature Communications · 65
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Triptonide potently suppresses pancreatic cancer cell-mediated vasculogenic mimicry by inhibiting expression of VE-cadherin and chemokine ligand 2 genes
2017 · Hongyan Han, Longsheng Du, et al. · European Journal of Pharmacology · 56
Scalable Total Synthesis of (−)-Triptonide: Serendipitous Discovery of a Visible-Light-Promoted Olefin Coupling Initiated by Metal-Catalyzed Hydrogen Atom Transfer (MHAT)
2022 · Xianhe Fang, Nan Zhang, et al. · Journal of the American Chemical Society · 54
Total synthesis of (.+-.)-triptonide and (.+-.)-triptolide
1982 · Lee C. Garver, Eugene E. Van Tamelen · Journal of the American Chemical Society · 53
Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin
2016 · Jessica Chinison, Jose S. Aguilar, et al. · Scientific Reports · 49
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Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Triperygium wilfordii and scale-up
2008 · Aihua Peng, Rui Li, et al. · Journal of Chromatography A · 43
Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells
2014 · Lingge He, Zhuangyan Liang, et al. · Cellular and Molecular Immunology · 41
Regioselective routes towards 14-hydroxyabietane diterpenes. A formal synthesis of immunosuppressant (−)-triptolide from (+)-abietic acid
2007 · Enrique Alvarez-Manzaneda, Rachid Chahboun, et al. · Tetrahedron · 41
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy
2020 · Bo Yang, Bin Zhang, et al. · Cell Death and Differentiation · 40
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Targeting of multiple senescence-promoting genes and signaling pathways by triptonide induces complete senescence of acute myeloid leukemia cells
2016 · Yanyan Pan, Mei Meng, et al. · Biochemical Pharmacology · 40
Total synthesis of triptolide and triptonide
1980 · Richard S. Buckanin, Samuel J. Chen, et al. · Journal of the American Chemical Society · 40
Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins
2021 · Mengli Zhang, Mei Meng, et al. · Breast Cancer Research · 38
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Triptonide inhibits lung cancer cell tumorigenicity by selectively attenuating the Shh-Gli1 signaling pathway
2019 · Mengli Zhang, Shijie Tan, et al. · Toxicology and Applied Pharmacology · 38
Divergent Total Synthesis of Triptolide, Triptonide, Tripdiolide, 16-Hydroxytriptolide, and Their Analogues
2014 · Hongtao Xu, Huanyu Tang, et al. · The Journal of Organic Chemistry · 38
Triptonide effectively suppresses gastric tumor growth and metastasis through inhibition of the oncogenic Notch1 and NF-κB signaling pathways
2019 · Shufen Xiang, Zhe Zhao, et al. · Toxicology and Applied Pharmacology · 37
Total synthesis of racemic triptolide and triptonide
1982 · Chee Kong Lai, Richard S. Buckanin, et al. · The Journal of Organic Chemistry · 35
Biogenetic-type total synthesis of (.+-.)-triptonide and (.+-.)-triptolide
1982 · E. E. Van Tamelen, T. M. Leiden · Journal of the American Chemical Society · 35
Works count: 167
Citation count: 2,293
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