Keyword

TRPML2

Description: A transient receptor potential mucolipin ion channel encoded by MCOLN2, studied for its roles in endolysosomal function and immune signaling.

Primary topic: Calcium signaling and nucleotide metabolism (79%)

Wikidata ID: wiki/Q18053790

OpenAlex ID: keywords/trpml2

Mucolipins: Intracellular TRPML1‐3 channels

2010 · Xiping Cheng, Dongbiao Shen, et al. · FEBS Letters · 268

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The role of TRPMLs in endolysosomal trafficking and function

2014 · Kartik Venkatachalam, Ching-On Wong, et al. · Cell Calcium · 204

TRPML1: The Ca(2+)retaker of the lysosome

2017 · Simone Di Paola, Anna Scotto-Rosato, et al. · Cell Calcium · 155

Lysosomal Localization of TRPML3 Depends on TRPML2 and the Mucolipidosis-associated Protein TRPML1

2006 · Kartik Venkatachalam, Thomas Hofmann, et al. · Journal of Biological Chemistry · 148

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TRPMLs: in sickness and in health

2009 · Rosa Puertollano, Kirill Kiselyov · American Journal of Physiology-Renal Physiology · 128

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

2018 · Eva Plesch, Cheng-Chang Chen, et al. · eLife · 105

Calciotropic and Magnesiotropic TRP Channels

2008 · Joost G. J. Hoenderop, René J. M. Bindels · Physiology · 102

Novel Role of TRPML2 in the Regulation of the Innate Immune Response

2015 · Lu Sun, Yinan Hua, et al. · The Journal of Immunology · 91

The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1

2009 · Mohammad A. Samie, Christian Grimm, et al. · Pflügers Archiv - European Journal of Physiology · 81

Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy

2010 · David A. Zeevi, Shaya Lev, et al. · Journal of Cell Science · 68

TRPML: Transporters of metals in lysosomes essential for cell survival?

2011 · Kirill Kiselyov, Grace A. Colletti, et al. · Cell Calcium · 66

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression

2016 · Maria Beatrice Morelli, Massimo Nabissi, et al. · Oncotarget · 64

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Functional multimerization of mucolipin channel proteins

2009 · Cyntia Curcio‐Morelli, Peng Zhang, et al. · Journal of Cellular Physiology · 61

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A potentially dynamic lysosomal role for the endogenous TRPML proteins

2009 · David A. Zeevi, Ayala Frumkin, et al. · The Journal of Pathology · 61

TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles

2020 · Cheng-Chang Chen, Einar Krogsaeter, et al. · Science Advances · 60

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The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function

2015 · Math P. Cuajungco, Joshua Silva, et al. · Pflügers Archiv - European Journal of Physiology · 56

Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration

2009 · Shaya Lev, David A. Zeevi, et al. · Journal of Biological Chemistry · 55

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Endolysosomal Ca2+ Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!

2018 · Pawan Faris, Mudhir Shekha, et al. · Cancers · 52

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TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes

2006 · Yumei Song, Rashmi Dayalu, et al. · European Journal of Cell Biology · 48

Constitutive Activity of TRPML2 and TRPML3 Channels versus Activation by Low Extracellular Sodium and Small Molecules

2012 · C. Grimm, S. Jors, et al. · Journal of Biological Chemistry · 43

ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity

2020 · Zhiqiang Xia, Luyao Wang, et al. · Antiviral Research · 42

Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3

2020 · Charlotte Leser, Marco Keller, et al. · European Journal of Medicinal Chemistry · 39

Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis

2019 · Abeer F. Alharbi, John Parrington · Frontiers in Cell and Developmental Biology · 36

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Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses

2020 · Giorgio Santoni, Maria Beatrice Morelli, et al. · Frontiers in Immunology · 34

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Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation

2020 · Cheng-Chang Chen, Einar Krogsaeter, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 33

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Works count: 104

Citation count: 2,483