Get started
Keyword

TRPML3

Description: A mucolipin protein encoded by the MCOLN3 gene that forms an ion channel involved in intracellular membrane function.
Wikidata ID: wiki/Q18041726
OpenAlex ID: keywords/trpml3
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
2017 · Qingfeng Chen, Ji She, et al. · Nature · 304
A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion
2015 · Yuxuan Miao, Guojie Li, et al. · Cell · 296
PDF
Mucolipins: Intracellular TRPML1‐3 channels
2010 · Xiping Cheng, Dongbiao Shen, et al. · FEBS Letters · 268
PDF
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice
2007 · Haoxing Xu, Markus Delling, et al. · Proceedings of the National Academy of Sciences · 217
The role of TRPMLs in endolysosomal trafficking and function
2014 · Kartik Venkatachalam, Ching-On Wong, et al. · Cell Calcium · 204
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
2021 · Di Chen, Qiaoxia Zheng, et al. · Developmental Cell · 201
PDF
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse
2007 · Christian Grimm, Math P. Cuajungco, et al. · Proceedings of the National Academy of Sciences · 168
The Ca2+ Channel TRPML3 Regulates Membrane Trafficking and Autophagy
2009 · Hyun Jin Kim, Abigail A. Soyombo, et al. · Traffic · 163
PDF
TRPML1: The Ca(2+)retaker of the lysosome
2017 · Simone Di Paola, Anna Scotto-Rosato, et al. · Cell Calcium · 155
Lysosomal Localization of TRPML3 Depends on TRPML2 and the Mucolipidosis-associated Protein TRPML1
2006 · Kartik Venkatachalam, Thomas Hofmann, et al. · Journal of Biological Chemistry · 148
PDF
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration
2007 · Keiichi Nagata, Lili Zheng, et al. · Proceedings of the National Academy of Sciences · 139
Gain-of-function Mutation in TRPML3 Causes the Mouse Varitint-Waddler Phenotype
2007 · Hyun Jin Kim, Qin Li, et al. · Journal of Biological Chemistry · 131
Small Molecule Activators of TRPML3
2010 · Christian Grimm, Simone Jörs, et al. · Chemistry & Biology · 128
TRPMLs: in sickness and in health
2009 · Rosa Puertollano, Kirill Kiselyov · American Journal of Physiology-Renal Physiology · 128
Differential regulation of TRP channels in a rat model of neuropathic pain
2009 · Susanne Staaf, Sandra Oerther, et al. · Pain · 126
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
2017 · Marscha Hirschi, Mark A. Herzik Jr, et al. · Nature · 122
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint‐waddler phenotype
2008 · Hyun Jin Kim, Qin Li, et al. · The EMBO Journal · 107
PDF
Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels
2011 · Soichiro Yamaguchi, Archana Jha, et al. · Journal of Biological Chemistry · 99
What is the hair cell transduction channel?
2006 · David P. Corey · The Journal of Physiology · 96
Novel Role of TRPML2 in the Regulation of the Innate Immune Response
2015 · Lu Sun, Yinan Hua, et al. · The Journal of Immunology · 91
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
2017 · Xiaoyuan Zhou, Minghui Li, et al. · Nature Structural & Molecular Biology · 84
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1
2009 · Mohammad A. Samie, Christian Grimm, et al. · Pflügers Archiv - European Journal of Physiology · 81
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice
2022 · Barbara Spix, Elisabeth S. Butz, et al. · Nature Communications · 77
PDF
Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis
2012 · Christian Grimm, Sami Hassan, et al. · Journal of Pharmacology and Experimental Therapeutics · 76
TRP channels as candidates for hearing and balance abnormalities in vertebrates
2007 · Math P. Cuajungco, Christian Grimm, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 72
PDF
Works count: 138
Citation count: 5,408
Year
Topic
Type