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TRPV1
Description:
A heat- and chemical-sensitive ion channel protein involved in pain and sensory signaling, especially in peripheral neurons.
Primary topic:
Ion Channels and Receptors (45%)
Related topics:
Ion Channels and Receptors (45%),
Pain Mechanisms and Treatments (13%)
Wikidata ID:
wiki/Q413209
OpenAlex ID:
keywords/trpv1
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000
·
M. J. Caterina
, A. Leffler
, et al.
·
Science
·
3,531
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003
·
Gina M. Story
, Andrea M. Peier
, et al.
·
Cell
·
2,486
PDF
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999
·
Peter M. Zygmunt
, Jesper Petersson
, et al.
·
Nature
·
2,144
Vanilloid (Capsaicin) Receptors and Mechanisms
1999
·
Arpad Szallasi
, Peter M. Blumberg
·
Pharmacological Reviews
·
1,903
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
2004
·
Michael Bandell
, Gina M Story
, et al.
·
Neuron
·
1,827
PDF
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
1991
·
P Holzer
·
Pharmacological Reviews
·
1,774
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000
·
John B. Davis
, Julie Gray
, et al.
·
Nature
·
1,760
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013
·
Maofu Liao
, Erhu Cao
, et al.
·
Nature
·
1,687
PDF
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
2010
·
R.G. Pertwee
, A.C. Howlett
, et al.
·
Pharmacological Reviews
·
1,605
PDF
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001
·
Michael J Caterina
, David Julius
·
Annual Review of Neuroscience
·
1,575
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
2001
·
Tiziana Bisogno
, Lumír Hanuš
, et al.
·
British Journal of Pharmacology
·
1,311
PDF
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001
·
Huai-hu Chuang
, Elizabeth D. Prescott
, et al.
·
Nature
·
1,258
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
2002
·
Ru-Rong Ji
, Tarek A. Samad
, et al.
·
Neuron
·
1,238
PDF
TRP Channels and Pain
2013
·
David Julius
·
Annual Review of Cell and Developmental Biology
·
1,140
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
2004
·
Thomas Voets
, Guy Droogmans
, et al.
·
Nature
·
1,070
PDF
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
2000
·
Sun Wook Hwang
, Hawon Cho
, et al.
·
Proceedings of the National Academy of Sciences
·
1,048
Heat-Evoked Activation of the Ion Channel, TRPV4
2002
·
Ali Deniz Güler
, Hyosang Lee
, et al.
·
Journal of Neuroscience
·
1,031
PDF
TRPV1 structures in distinct conformations reveal activation mechanisms
2013
·
Erhu Cao
, Maofu Liao
, et al.
·
Nature
·
1,028
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
2014
·
Orrin Devinsky
, Maria Roberta Cilio
, et al.
·
Epilepsia
·
997
Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
2010
·
Luciano De Petrocellis
, Alessia Ligresti
, et al.
·
British Journal of Pharmacology
·
941
PDF
TRPV3 is a calcium-permeable temperature-sensitive cation channel
2002
·
Haoxing Xu
, I. Scott Ramsey
, et al.
·
Nature
·
920
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007
·
Arpad Szallasi
, Daniel N. Cortright
, et al.
·
Nature Reviews Drug Discovery
·
881
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002
·
Sven-Eric Jordt
, David Julius
·
Cell
·
880
PDF
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
2000
·
Éva Mezey
, Zsuzsanna E. Tóth
, et al.
·
Proceedings of the National Academy of Sciences
·
852
The neuropharmacology of capsaicin: review of some recent observations.
1986
·
S H Buck
, T F Burks
·
Pharmacological Reviews
·
845
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Works count:
14,350
Citation count:
425,300
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