Keyword

TSC1

Description: A human protein-coding gene that encodes hamartin, a tumor suppressor involved in mTOR signaling, cell growth, and cellular organization.

Primary topic: Tuberous Sclerosis Complex Research (49%)

Wikidata ID: wiki/Q14908113

OpenAlex ID: keywords/tsc1

The Tuberous Sclerosis Complex

2006 · Peter B. Crino, Katherine L. Nathanson, et al. · New England Journal of Medicine · 1,801

Perturbations of the AKT signaling pathway in human cancer

2005 · Deborah A Altomare, Joseph R Testa · Oncogene · 1,330

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

2004 · Pankaj Kapahi, Brian M Zid, et al. · Current Biology · 1,293

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 · Diane C Fingar, John Blenis · Oncogene · 1,249

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 · Laura S. Harrington, Greg M. Findlay, et al. · The Journal of Cell Biology · 1,125

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 · Attila Garami, Fried J.T Zwartkruis, et al. · Molecular Cell · 1,043

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Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs

2001 · Sandra L. Dabora, Sergiusz Jozwiak, et al. · The American Journal of Human Genetics · 1,003

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 · Yong Zhang, Xinsheng Gao, et al. · Nature Cell Biology · 924

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

2012 · Peter T. Tsai, Court Hull, et al. · Nature · 888

Tuberous sclerosis complex

2016 · Elizabeth P. Henske, Sergiusz Jóźwiak, et al. · Nature Reviews Disease Primers · 860

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 · Andrew R. Tee, Diane C. Fingar, et al. · Proceedings of the National Academy of Sciences · 827

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 · O.Jameel Shah, Zhiyong Wang, et al. · Current Biology · 799

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The genetic basis of kidney cancer: a metabolic disease

2010 · W. Marston Linehan, Ramaprasad Srinivasan, et al. · Nature Reviews Urology · 744

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations

2021 · Hope Northrup, Mary E. Aronow, et al. · Pediatric Neurology · 740

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mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

2009 · Chong Chen, Yu Liu, et al. · Science Signaling · 680

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 · Xinsheng Gao, Yong Zhang, et al. · Nature Cell Biology · 672

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 · D. J. Kwiatkowski · Human Molecular Genetics · 667

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

2011 · Jessica L. Yecies, Hui H. Zhang, et al. · Cell Metabolism · 659

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

2010 · Shomit Sengupta, Timothy R. Peterson, et al. · Nature · 645

IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

2007 · Dung-Fang Lee, Hsu-Ping Kuo, et al. · Cell · 637

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

2008 · Ling‐Hui Zeng, Lin Xu, et al. · Annals of Neurology · 636

The TSC-mTOR pathway regulates macrophage polarization

2013 · Vanessa Byles, Anthony J. Covarrubias, et al. · Nature Communications · 633

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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1998 · M van Slegtenhorst · Human Molecular Genetics · 568

PEComas: the past, the present and the future

2007 · Guido Martignoni, Maurizio Pea, et al. · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 551

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The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 · Nicolas Tapon, Naoto Ito, et al. · Cell · 542

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Works count: 3,039

Citation count: 101,700