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Keyword

TSC2

Description: A human protein-coding gene involved in the tuberous sclerosis complex and regulation of mTOR signaling.
Wikidata ID: wiki/Q18032199
OpenAlex ID: keywords/tsc2
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 · Ken Inoki, Tianqing Zhu, et al. · Cell · 3,907
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
2008 · Dana M. Gwinn, David B. Shackelford, et al. · Molecular Cell · 3,840
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
2002 · Ken Inoki, Yong Li, et al. · Nature Cell Biology · 3,081
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
2003 · Ken Inoki, Yong Li, et al. · Genes & Development · 1,907
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The Tuberous Sclerosis Complex
2006 · Peter B. Crino, Katherine L. Nathanson, et al. · New England Journal of Medicine · 1,801
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006 · David A. Guertin, Deanna M. Stevens, et al. · Developmental Cell · 1,415
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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 · Ken Inoki, Hongjiao Ouyang, et al. · Cell · 1,379
Perturbations of the AKT signaling pathway in human cancer
2005 · Deborah A Altomare, Joseph R Testa · Oncogene · 1,330
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
2008 · Andrei V. Budanov, Michael Karin · Cell · 1,323
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Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
2004 · Pankaj Kapahi, Brian M Zid, et al. · Current Biology · 1,293
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Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 · Li Ma, Zhenbang Chen, et al. · Cell · 1,266
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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 · Diane C Fingar, John Blenis · Oncogene · 1,249
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
2007 · Emilie Vander Haar, Seong-il Lee, et al. · Nature Cell Biology · 1,190
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
2014 · Guomei Tang, Kathryn Gudsnuk, et al. · Neuron · 1,145
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The AMP-activated protein kinase pathway – new players upstream and downstream
2004 · D. Grahame Hardie · Journal of Cell Science · 1,143
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
2004 · Laura S. Harrington, Greg M. Findlay, et al. · The Journal of Cell Biology · 1,124
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004 · Reuben J Shaw, Nabeel Bardeesy, et al. · Cancer Cell · 1,077
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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
2003 · Attila Garami, Fried J.T Zwartkruis, et al. · Molecular Cell · 1,043
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Rheb Binds and Regulates the mTOR Kinase
2005 · Xiaomeng Long, Yenshou Lin, et al. · Current Biology · 1,005
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Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs
2001 · Sandra L. Dabora, Sergiusz Jozwiak, et al. · The American Journal of Human Genetics · 1,003
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Akt regulates growth by directly phosphorylating Tsc2
2002 · Christopher J. Potter, Laura G. Pedraza, et al. · Nature Cell Biology · 959
Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells
2007 · Ryan J.O. Dowling, Mahvash Zakikhani, et al. · Cancer Research · 933
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
2003 · Yong Zhang, Xinsheng Gao, et al. · Nature Cell Biology · 924
Tuberous sclerosis complex
2016 · Elizabeth P. Henske, Sergiusz Jóźwiak, et al. · Nature Reviews Disease Primers · 859
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
2002 · Andrew R. Tee, Diane C. Fingar, et al. · Proceedings of the National Academy of Sciences · 827
Works count: 4,036
Citation count: 153,600
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