Keyword

cancer mutations

Description: Genetic alterations found in cancer cells that can affect protein structure, function, or interactions and contribute to tumor development.

Primary topic: Cancer Genomics and Diagnostics (22%)

OpenAlex ID: keywords/tumor-mutations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 · Jerry M. Adams, Suzanne Cory · Science · 5,334

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 · Reuben J. Shaw, Lewis C. Cantley · Nature · 2,010

Definition of a consensus binding site for p53

1992 · Wafik S. El-Deiry, Scott E. Kern, et al. · Nature Genetics · 1,986

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

2019 · Jüri Reimand, Ruth Isserlin, et al. · Nature Protocols · 1,956

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The Concept of Synthetic Lethality in the Context of Anticancer Therapy

2005 · William G. Kaelin · Nature reviews. Cancer · 1,379

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

2004 · S Bamford, E Dawson, et al. · British Journal of Cancer · 1,267

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Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

2017 · Daniela Sia, Yang Jiao, et al. · Gastroenterology · 971

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

2014 · Jianjun Zhang, Junya Fujimoto, et al. · Science · 963

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

2003 · Shunsuke Kato, Shuang-Yin Han, et al. · Proceedings of the National Academy of Sciences · 874

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

2002 · Nicolas Tapon, Kieran F. Harvey, et al. · Cell · 856

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

2015 · Cigall Kadoch, Gerald R. Crabtree · Science Advances · 828

Mitochondrial reactive oxygen species and cancer

2014 · Lucas B Sullivan, Navdeep S Chandel · Cancer & Metabolism · 786

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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

2012 · Huilin Shao, Jaehoon Chung, et al. · Nature Medicine · 759

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Structural Biology of the Tumor Suppressor p53

2008 · Andreas C. Joerger, Alan R. Fersht · Annual Review of Biochemistry · 693

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

2014 · Carsten Linnemann, Marit M van Buuren, et al. · Nature Medicine · 679

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DISEASES: Text mining and data integration of disease–gene associations

2014 · Sune Pletscher-Frankild, Albert Pallejà, et al. · Methods · 590

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Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression

2016 · Suzan Ruijtenberg, Sander van den Heuvel · Cell Cycle · 553

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Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

2020 · Sri Krishna, Frank J. Lowery, et al. · Science · 547

From neural development to cognition: unexpected roles for chromatin

2013 · Jehnna L. Ronan, Wei Wu, et al. · Nature Reviews Genetics · 542

The INK4A/ARF locus and its two gene products

1999 · Norman E Sharpless, Ronald A DePinho · Current Opinion in Genetics & Development · 534

Global topological features of cancer proteins in the human interactome

2006 · Pall F. Jonsson, Paul A. Bates · Bioinformatics · 496

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Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase

1998 · Jun Yan, Sandrine Roy, et al. · Journal of Biological Chemistry · 477

How many mutations are required for tumorigenesis? implications from human cancer data

1993 · Allan Balmain, J. Carl Barrett, et al. · Molecular Carcinogenesis · 464

ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

2012 · Jennifer N. Wu, Charles W.M. Roberts · Cancer Discovery · 456

Linear Motif Atlas for Phosphorylation-Dependent Signaling

2008 · Martin Lee Miller, Lars Juhl Jensen, et al. · Science Signaling · 442

Works count: 2,551

Citation count: 68,020