Keyword

TYK2

Description: TYK2 is a protein-coding gene encoding a Janus kinase involved in cytokine signaling, immune function, and related biomedical research.

Primary topic: Cytokine Signaling Pathways and Interactions (26%)

Wikidata ID: wiki/Q14914487

OpenAlex ID: keywords/tyk2

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

2010 · Andre Franke, Dermot P B McGovern, et al. · Nature Genetics · 2,518

PDF

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 · C. Schindler, J. E. Darnell · Annual Review of Biochemistry · 1,810

The JAK-STAT Pathway at Twenty

2012 · George R. Stark, James E. Darnell · Immunity · 1,518

PDF

Genetic mechanisms of critical illness in COVID-19

2020 · The GenOMICC Investigators, Erola Pairo-Castineira, et al. · Nature · 1,367

PDF

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 · Christi Parham, Madaline Chirica, et al. · The Journal of Immunology · 1,296

Structure and function of a new STAT-induced STAT inhibitor

1997 · Tetsuji Naka, Masashi Narazaki, et al. · Nature · 1,288

PDF

Janus kinases in immune cell signaling

2009 · Kamran Ghoreschi, Arian Laurence, et al. · Immunological Reviews · 1,144

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

2010 · Amy Strange, Chris C A Spencer, et al. · Nature Genetics · 1,048

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 · Laura Velazquez, Marc Fellous, et al. · Cell · 873

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 · Mathias Müller, James Briscoe, et al. · Nature · 761

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 · Mario B. Marrero, Bernhard Schieffer, et al. · Nature · 745

Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity

2006 · Yoshiyuki Minegishi, Masako Saito, et al. · Immunity · 702

PDF

Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction

2025 · Saro Passaro, Gabriele Corso, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 687

Interferons α and β as Immune Regulators—A New Look

2001 · Christine A Biron · Immunity · 667

PDF

The Janus kinases (Jaks)

2004 · Kunihiro Yamaoka, Pipsa Saharinen, et al. · Genome biology · 642

PDF

The immunogenetics of Psoriasis: A comprehensive review

2015 · Jamie L. Harden, James G. Krueger, et al. · Journal of Autoimmunity · 618

Signaling Through the Hematopoietic Cytokine Receptors

1995 · J N Ihle, B A Witthuhn, et al. · Annual Review of Immunology · 612

Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus

2005 · Snaevar Sigurdsson, Gunnel Nordmark, et al. · The American Journal of Human Genetics · 608

Activation of the JAK-STAT pathway by reactive oxygen species

1998 · Amy R. Simon, Usha Rai, et al. · American Journal of Physiology-Cell Physiology · 598

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

2004 · Wendy T. Watford, Bruce D. Hissong, et al. · Immunological Reviews · 572

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

2009 · Melanie Bahlo, David R Booth, et al. · Nature Genetics · 550

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 · Ke Shuai, Andrew Ziemiecki, et al. · Nature · 509

TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B

2001 · Michael P. Myers, Jannik N. Andersen, et al. · Journal of Biological Chemistry · 475

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 · C M Bacon, E F Petricoin, et al. · Proceedings of the National Academy of Sciences · 449

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

2015 · Ramona Crescenzo, Francesco Abate, et al. · Cancer Cell · 443

PDF

Works count: 1,873

Citation count: 77,790