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VP35
Description:
A viral protein found in Ebola and Lloviu viruses that can antagonize innate immune responses and contribute to viral replication.
Primary topic:
Viral Infections and Outbreaks Research (55%)
Related topics:
Viral Infections and Outbreaks Research (55%),
Computational Drug Discovery Methods (12%),
interferon and immune responses (10%)
OpenAlex ID:
keywords/vp35
Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems
1999
·
Elke Mühlberger
, Michael Weik
, et al.
·
Journal of Virology
·
487
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study
2010
·
Thomas W Geisbert
, Amy CH Lee
, et al.
·
The Lancet
·
464
PDF
Marburg Virus Vaccines Based upon Alphavirus Replicons Protect Guinea Pigs and Nonhuman Primates
1998
·
Michael Hevey
, Diane Negley
, et al.
·
Virology
·
262
PDF
Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography
2012
·
Tanmay A. M. Bharat
, Takeshi Noda
, et al.
·
Proceedings of the National Academy of Sciences
·
252
PDF
Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKKε and TBK-1
2009
·
Kathleen C. Prins
, Washington B. Cárdenas
, et al.
·
Journal of Virology
·
241
The Assembly of Ebola Virus Nucleocapsid Requires Virion-Associated Proteins 35 and 24 and Posttranslational Modification of Nucleoprotein
2002
·
Yue Huang
, Ling Xu
, et al.
·
Molecular Cell
·
240
PDF
Three of the Four Nucleocapsid Proteins of Marburg Virus, NP, VP35, and L, Are Sufficient To Mediate Replication and Transcription of Marburg Virus-Specific Monocistronic Minigenomes
1998
·
Elke Mühlberger
, Beate Lötfering
, et al.
·
Journal of Virology
·
228
PDF
Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery
2009
·
Tsung-Hsien Chang
, Toru Kubota
, et al.
·
PLoS Pathogens
·
220
PDF
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35
2010
·
Daisy W Leung
, Kathleen C Prins
, et al.
·
Nature Structural & Molecular Biology
·
211
Descriptive analysis of Ebola virus proteins
1985
·
Luanne H. Elliott
, Michael P. Kiley
, et al.
·
Virology
·
203
Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome
2013
·
Priya Luthra
, Parameshwaran Ramanan
, et al.
·
Cell Host & Microbe
·
179
PDF
Evasion of Interferon Responses by Ebola and Marburg Viruses
2009
·
Christopher F. Basler
, Gaya K. Amarasinghe
·
Journal of Interferon & Cytokine Research
·
171
Interactions of Marburg Virus Nucleocapsid Proteins
1998
·
S. Becker
, C. Rinne
, et al.
·
Virology
·
170
PDF
Functional Mapping of the Nucleoprotein of Ebola Virus
2006
·
Shinji Watanabe
, Takeshi Noda
, et al.
·
Journal of Virology
·
163
Structure of the Ebola VP35 interferon inhibitory domain
2009
·
Daisy W. Leung
, Nathaniel D. Ginder
, et al.
·
Proceedings of the National Academy of Sciences
·
162
An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions
2015
·
Daisy W. Leung
, Dominika Borek
, et al.
·
Cell Reports
·
160
PDF
Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
2006
·
Kelly L Warfield
, Dana L Swenson
, et al.
·
PLoS Pathogens
·
157
PDF
Cryo-Electron Tomography of Marburg Virus Particles and Their Morphogenesis within Infected Cells
2011
·
Tanmay A. M. Bharat
, James D. Riches
, et al.
·
PLoS Biology
·
152
PDF
Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus
2008
·
Amy L. Hartman
, Brian H. Bird
, et al.
·
Journal of Virology
·
152
DNA vaccines encoding viral envelope proteins confer protective immunity against WSSV in black tiger shrimp
2007
·
Namita Rout
, Sudhir Kumar
, et al.
·
Vaccine
·
152
Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs
2010
·
Kathleen C. Prins
, Sebastien Delpeut
, et al.
·
Journal of Virology
·
145
The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells
2013
·
Asuka Nanbo
, Shinji Watanabe
, et al.
·
Scientific Reports
·
143
PDF
A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus
2004
·
Amy L. Hartman
, Jonathan S. Towner
, et al.
·
Virology
·
142
Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex
2015
·
Robert N. Kirchdoerfer
, Dafna M. Abelson
, et al.
·
Cell Reports
·
139
PDF
Ebola Virus VP35 Antagonizes PKR Activity through Its C-Terminal Interferon Inhibitory Domain
2009
·
Michael Schümann
, Thorsten Gantke
, et al.
·
Journal of Virology
·
139
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Works count:
470
Citation count:
11,970
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