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WISP3
Description:
WISP3, also called CCN6, is a human protein-coding gene studied in cell biology and disease research.
Primary topic:
Connective Tissue Growth Factor Research (28%)
Related topics:
Connective Tissue Growth Factor Research (28%),
Connective tissue disorders research (19%),
Osteoarthritis Treatment and Mechanisms (9%)
Wikidata ID:
wiki/Q18033472
OpenAlex ID:
keywords/wisp3
Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia
1999
·
Jennifer R. Hurvitz
, Wafaa M. Suwairi
, et al.
·
Nature Genetics
·
276
Genetic Analyses in a Sample of Individuals With High or Low BMD Shows Association With Multiple Wnt Pathway Genes
2007
·
Anne-Marie Sims
, Neil Shephard
, et al.
·
Journal of Bone and Mineral Research
·
156
WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
2002
·
Celina G Kleer
, Yanhong Zhang
, et al.
·
Oncogene
·
144
Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability
2005
·
Lin Thorstensen
, Guro E. Lind
, et al.
·
Neoplasia
·
122
PDF
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
2003
·
Celina G Kleer
, Yanhong Zhang
, et al.
·
Breast Cancer Research
·
101
PDF
Expression and regulation of CCN genes in murine osteoblasts
2005
·
Muriel S. Parisi
, Elizabetta Gazzerro
, et al.
·
Bone
·
95
WISP3 (CCN6) Is a Secreted Tumor-Suppressor Protein that Modulates IGF Signaling in Inflammatory Breast Cancer
2004
·
Celina G. Kleer
, Yanhong Zhang
, et al.
·
Neoplasia
·
92
PDF
The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): A review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals
2012
·
Nuria Garcia Segarra
, Laureane Mittaz
, et al.
·
American Journal of Medical Genetics Part C Seminars in Medical Genetics
·
91
The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling
2007
·
Yukio Nakamura
, Gilbert Weidinger
, et al.
·
Journal of Clinical Investigation
·
91
PDF
WISP3‐dependent regulation of type II collagen and aggrecan production in chondrocytes
2004
·
Malini Sen
, Yu‐Ho Cheng
, et al.
·
Arthritis & Rheumatism
·
84
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway
2023
·
Fei Zhou
, Jianguo Sun
, et al.
·
Experimental Hematology and Oncology
·
75
PDF
CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
2012
·
Anupama Pal
, Wei Huang
, et al.
·
Cancer Research
·
70
WISP3, the Gene Responsible for the Human Skeletal Disease Progressive Pseudorheumatoid Dysplasia, Is Not Essential for Skeletal Function in Mice
2004
·
Wendy E. Kutz
, Yaoqin Gong
, et al.
·
Molecular and Cellular Biology
·
68
CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
2011
·
Guadalupe Lorenzatti
, Wei Huang
, et al.
·
Journal of Cell Science
·
66
PDF
Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells
2005
·
Yanhong Zhang
, Quintin Pan
, et al.
·
Breast Cancer Research
·
65
PDF
Inhibition of CCN6 (Wnt-1-Induced Signaling Protein 3) Down-Regulates E-Cadherin in the Breast Epithelium through Induction of Snail and ZEB1
2008
·
Wei Huang
, Yanhong Zhang
, et al.
·
American Journal Of Pathology
·
63
PDF
Expression of WISPs and of Their Novel Alternative Variants in Human Hepatocellular Carcinoma Cells
2004
·
MELCHIORRE CERVELLO
, LYDIA GIANNITRAPANI
, et al.
·
Annals of the New York Academy of Sciences
·
53
Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
2010
·
B. Frank
, M. Hoffmeister
, et al.
·
Carcinogenesis
·
49
Oligogenic germline mutations identified in early non-smokers lung adenocarcinoma patients
2014
·
Alessandra Renieri
, Maria Antonietta Mencarelli
, et al.
·
Lung Cancer
·
44
WISP3 - IGF1 interaction regulates chondrocyte hypertrophy
2013
·
R. Srinivasa Rao
, Milan Patra
, et al.
·
Journal of Cell Science
·
41
Wnt‐1–inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis
2005
·
Rebecca Lamb
, Wendy Thomson
, et al.
·
Arthritis & Rheumatism
·
41
Progressive pseudorheumatoid dysplasia: a rare childhood disease
2018
·
Sofia Torreggiani
, Marta Torcoletti
, et al.
·
Rheumatology International
·
38
CCN6 (WISP3) as a New Regulator of the Epithelial Phenotype in Breast Cancer
2007
·
Celina G. Kleer
, Yanhong Zhang
, et al.
·
Cells Tissues Organs
·
34
Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis.
2004
·
Hyeonjoo Cheon
, David L Boyle
, et al.
·
PubMed
·
34
A descriptive analysis of 14 cases of progressive-psuedorheumatoid-arthropathy of childhood from south India: Review of literature in comparison with Juvenile Idiopathic Arthritis
2012
·
Alka V. Ekbote
, Debashish Danda
, et al.
·
Seminars in Arthritis and Rheumatism
·
33
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Works count:
189
Citation count:
3,079
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