Synthesis and Biological Activity
Description: This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.
Characteristic keywords: tetrahydroisoquinolines, isoquinoline alkaloids, isoquinoline derivatives, isoquinoline synthesis, tetrahydroisoquinoline alkaloids, tetrahydroisoquinoline derivatives, 3,4-dihydroisoquinolines, tetrahydroisoquinoline synthesis, Bischler-Napieralski reaction, dihydroisoquinolines, Bischler-Napieralski cyclization, naphthylisoquinoline alkaloids, 1,2-dihydroisoquinolines, isoquinolinium salts, homoveratrylamine, protoberberines, decahydroisoquinoline, tetrahydroprotoberberines, salsolidine, ecteinascidins, phthalideisoquinoline alkaloids, xylopinine, benzyltetrahydroisoquinoline alkaloids, aromatic amine synthesis
Sibling topics: MicroRNA in disease regulation, Breast Cancer Treatment Studies, Carcinogens and Genotoxicity Assessment, Cancer-related molecular mechanisms research, Protease and Inhibitor Mechanisms, Cancer, Hypoxia, and Metabolism, Cancer Genomics and Diagnostics, Sesquiterpenes and Asteraceae Studies, NF-κB Signaling Pathways, Cancer, Lipids, and Metabolism, Myxozoan Parasites in Aquatic Species, Beetle Biology and Toxicology Studies
Parent subfield: Cancer Research
Domain: Life Sciences
OpenAlex ID: T13971