Adhesion force, neutrophil membrane stiffness and systemic inflammation biomarkers in patients with chronic obstructive pulmonary disease and pulmonary hypertension
Year: 2014
Type: article
Study design: Observational Study
Abstract: The aim of this study was to investigate blood neutrophil functional properties and the relationships to systemic inflammation in order to better understand a role of systemic inflammation for PH occurrence in COPD patients. Methods . This was a local open comparative study involving 30 patients with COPD (15 patients with PH and 15 patients without PH). The blood neutrophil functional properties (cell membrane stiffness and adhesion force) were measured using the atomic force microscopy. The power spectroscopy was used to quantitatively assess the adhesion force and neutrophil cell membrane stiffness (the Young's modulus). Results . Blood neutrophil and thrombocyte numbers, CRP and fibrinogen levels were significantly higher in patients with COPD + PH compared to COPD patients without PH. Relationships were found between systemic inflammation biomarkers and systolic pulmonary artery pressure. Conclusion . The results demonstrated that the membrane stiffness and the adhesion force were significantly increased in COPD patients with PH compared to controls and to COPD patients without PH. These neutrophil parameters were closely related to systemic inflammation.
Source: PULMONOLOGIYA
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W10197084