Increased vitamin D levels at birth and in early infancy increase offspring allergy risk—evidence for involvement of epigenetic mechanisms
Year: 2015
Type: article
Abstract: Although a beneficial effect of vitamin D on health is widely accepted, its role in allergy development has been controversial. Both allergy-preventing and allergy-promoting effects have been reported. Thus, a deeper mechanistic understanding of how vitamin D is related to the regulation of immune reactivity and allergic inflammation is required. Vitamin D was shown to modify gene expression1 through binding of the vitamin D receptor to vitamin D response elements. However, only 26% of the genes identified as regulated by vitamin D have a vitamin D response element in proximity to their transcription start site (TSS),1 indicating that additional mechanisms are involved in the transcriptional control by vitamin D.
Authors: Kristin M. Junge, Tobias Bauer, Stefanie Geissler, Frank Hirche, Loreen Thürmann, Mario Bauer, Saskia Trump, Matthias Bieg, Dieter Weichenhan, Lei Gu, Jan-Philipp Mallm, Naveed Ishaque, Oliver Mücke, Stefan Röder, Gunda Herberth, Ulrike Diez, Michael Borte, Karsten Rippe, Christoph Plass, Carl Hermann, Gabriele I. Stangl, Roland Eils, Irina Lehmann
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
Funder: Deutsches Krebsforschungszentrum
OpenAlex ID: W1171364026