Serotype distribution ofStreptococcus pneumoniaein children with invasive diseases in Turkey: 2008–2014
Year: 2015
Type: article
Study design: Observational Study
Abstract: Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes of pneumococcal strains causing IPD in children in Turkey and emphasize the change in the serotypes before and after vaccination with 7-valent pneumococcal conjugate vaccine (PCV-7) was included and PCV-13 was newly changed in Turkish National Immunization Program. Streptococcus pneumoniae strains were isolated at 22 different hospitals of Turkey, which provide healthcare services to approximately 65% of the Turkish population. Of the 335 diagnosed cases with S. pneumoniae over the whole period of 2008-2014, the most common vaccine serotypes were 19F (15.8%), 6B (5.9%), 14 (5.9%), and 3 (5.9%). During the first 5 y of age, which is the target population for vaccination, the potential serotype coverage ranged from 57.5 % to 36.8%, from 65.0% to 44.7%, and from 77.4% to 60.5% for PCV-7, PCV-10, and PCV-13 in 2008-2014, respectively. The ratio of non-vaccine serotypes was 27.2% in 2008-2010 whereas was 37.6% in 2011-2014 (p=0.045). S. penumoniae serotypes was less non-susceptible to penicillin as compared to our previous results (33.7 vs 16.5 %, p=0.001). The reduction of those serotype coverage in years may be attributed to increasing vaccinated children in Turkey and the increasing non-vaccine serotype may be explained by serotype replacement. Our ongoing IPD surveillance is a significant source of information for the decision-making processes on pneumococcal vaccination.
Authors: Mehmet Ceyhan, Yasemin Ozsurekci, Nezahat Gürler, Lütfiye Öksüz, Sohret Aydemir, Sengul Ozkan, Serife Yuksekkaya, Melike Keser Emiroglu, Meral Gültekin, Akgün Yaman, Abdurrahman Kiremitci, Keramettin Yanık, Arzu Karli, Hatice Ozcinar, Faruk Aydin, Gulcin Bayramoglu, Yasemin Zer, Zeynep Gulay, Efgan Dogan Gayyurhan, Mustafa Gül, Cüneyt Özakın, Hüseyin Güdücüoğlu, Duygu Perçin, Nezahat Akpolat, Candan Ozturk, Yıldız Camcıoğlu, Eda Karadağ Öncel, Melda Çelik, Laser Şanal, Hakan Uslu
Institutions: Hacettepe University, Istanbul University-Cerrahpaşa, Istanbul University, Ege University, Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Konya Eğitim ve Araştırma Hastanesi, Selçuk University, Akdeniz University, Cukurova University, Ondokuz Mayıs University, Karadeniz Technical University, Gaziantep University, Dokuz Eylül University, Gaziantep Children's Hospital, Kahramanmaraş Sütçü İmam University, Bursa Uludağ Üni̇versi̇tesi̇, Van Yüzüncü Yıl Üniversitesi, Erciyes University, Dicle University, Mersin Üniversitesi, Atatürk University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Pfizer
OpenAlex ID: W1237108126