Work

Production of a Family of Kinase-inhibiting Lactones from Fungal.

Year: 1999

Type: article

Abstract: During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of the compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of media composition.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.52.1077

Authors: ANNE DOMBROWSKI, ROSALIND JENKINS, SUSAN RAGHOOBAR, GERALD BILLS, JON POLISHOOK, FERNANDO PELÁEZ, BRUCE BURGESS, ANNIE ZHAO, LEEYUAN HUANG, YAN ZHANG, MICHAEL GOETZ

Institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), MSD (Spain)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W125601491

FWCI: 0.785

Cites: 13

Cited by: 27

Related to: 10