Gallbladder cancer: adenoma-carcinoma or dysplasia-carcinoma sequence?
Year: 2008
Type: article
Study design: Case Report
Abstract: Gallbladder carcinoma is the sixth most common carcinoma of the digestive tract, with an incidence of 2.5 cases per 100,000 in the United States.1 There is a strong association between cholelithiasis and gallbladder cancer, with gallstones found in nearly 80% of all cases. Other risk factors for gallbladder carcinoma include a calcified gallbladder (known as porcelain gallbladder), a long common channel, and a chronic typhoid carrier state. Adenomas figure less prominently or not at all in the list of precursors.2
Unlike the colon, in which the concept of a definite adenoma-carcinoma sequence is accepted, in the gallbladder the relationship between adenoma and carcinoma is nebulous. Here, we present the case of a Bangladeshi man who underwent surgery for a polypoid lesion in the gallbladder detected incidentally on computed tomography scan in whom a gallbladder carcinoma was found arising from an adenoma.
Source: PubMed Central
Authors: Vivek Trivedi, Vivek V Gumaste, Shaojun Liu, Joel Baum
Institution: City University of New York
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W126785488