Year: 1998
Type: article
Abstract: During the production of cytoscatic drugs, a bulk of highly dangerous wastes with mucagenic and carcinogenic properties, are generated. This waste should be treated before pouring them into the sewerage system in order to guarantee the protection of the environmem. In this work, an analytical HPLC method for the monitoring of the wastes generated during the production of 5-tluorouracil (5-FU) and cytarabine was developed and validated. For each method, the results corresponding to the validation parameters: linearity, range, accuracy, precision, limit of deteclion and limit of quantification are reported. A1tificial wastes at severa! concentrations of both cytostatics (pH = 3 and 7) using ozone, as inactivating agent, were treated. The possibilicy of employing the oxidizing properties of ozone for the inactivation of dangerous wastes from the production process of those drugs was demonstrated.
Source: Revista CENIC. Ciencias químicas
Language: Spanish
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W133847656