The Correlation between Brain Derived Neurotrophic Factor (BDNF) Level and Motor Development of Children Aged Under 2 Years in Timor Tengah Selatan Nusa Tenggara Timur
Year: 2015
Type: article
Study design: Observational Study
Abstract: BDNF is neurotrophin which widely distributed in the CNS that regulate axonal and dendritic growth, synaptic \nstructure and plasticity, neurotransmitter release and long-term potentiation (LTP) related to the learning \nprocess. Motor development depends on the formation of the specific connections between corticospinal axonal \nand motor circuits in the contralateral of spinal cord. The aim of this study was to analyze the correlation \nbetween the level of BDNF and motor development of children aged under 2 years. This was a cross-sectional \nstudy in regency of Timor Tengah Selatan province of Nusa Tenggara Timur. Participants were 75 children aged \n6 ??? 20 months who met the inclusion and exclusion criteria. On subjects performed BDNF levels test and \nmeasurement of motor development using a questionnaire for DDST (Denver Developmental Screening Test). \nStatistical analysis was performed using t-independent test. Results shown that by using t-independent test, there \nwas a significant correlation between BDNF levels and motor development. Motor development obtained \nsignificantly better at BDNF levels 1,083??1,722 ng/ml in the category of normal motor development compared \nto BDNF levels 0,031??0,105 ng/ml in the category of caution motor development.
Authors: Rita Rita, Suryani Suryani, Veni Hadju, Jumraini Tammasse
Language: English
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: diamond
OpenAlex ID: W1464701394