Work

Long-term persistent infection of swine monocytes/macrophages with African swine fever virus

Year: 1994

Type: article

Abstract: Long-term persistent infection was established in 100% of pigs (n = 19) experimentally infected with African swine fever virus (ASFV). Viral DNA was detected in peripheral blood mononuclear leukocytes (PBML) at greater than 500 days postinfection by a PCR assay. Infectious virus was not, however, isolated from the same PBML samples. In cell fractionation studies of PBML, monocytes/macrophages were found to harbor viral DNA during the persistent phase of infection. This result indicates that monocytes/macrophages are persistently infected with ASFV and that ASFV-swine monocyte/macrophage interactions can result in either lytic or persistent infection.

Source: Journal of Virology

DOI: 10.1128/jvi.68.1.580-583.1994

Authors: C Carrillo, M V Borca, C L Afonso, D V Onisk, D L Rock

Institutions: Agricultural Research Service, United States Department of Agriculture, Plum Island Animal Disease Center

Language: English

Topic: Animal Disease Management and Epidemiology

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1491294375