Spinal plasticity following intermittent hypoxia: implications for spinal injury
Year: 2010
Type: review
Abstract: Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain-derived neurotrophic factor, activation of its high-affinity receptor, tropomyosin-related kinase B, and extracellular-related kinase mitogen-activated protein kinase signaling in or near phrenic motor neurons. Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury. Because repetitive AIH induces phenotypic plasticity in respiratory motor neurons, it may restore respiratory motor function in patients with incomplete spinal injury.
Institution: University of Wisconsin–Madison
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Mechanisms of respiratory long-term facilitation, Enhancement of Phrenic Long-Term Facilitation Following Intermittent Hypoxia, G3372084085, G4073842301, Stem Cell Therapy and Growth Factor Therapy for ALS, Respiratory plasticity and spinal cord Injury, Integrated Training For Physician-Scientists, Respiratory Plasticity and Spinal Cord Injury, Respiratory Neurobiology, G987370029
OpenAlex ID: W1491908576