Work

Nonbiological Conversion of Cephalosporin C to a New Antibiotic by Sodium Thiosulfate

Year: 1963

Type: article

Abstract: The apparent stimulation of cephalosporin C biosynthesis by sodium thiosulfate is due to a nonbiological conversion of cephalosporin C to a new derivative, cephalosporin C(x). The new compound is more active than cephalosporin C against the assay organism, Escherichia coli W-208. Cephalosporin C(x) retains the properties of ultraviolet absorption and resistance to penicillinase, but migrates more slowly than cephalosporin C in the paper-chromatographic system used.

Source: Applied Microbiology

DOI: 10.1128/am.11.1.58-61.1963

Authors: A. L. Demain, Joanne F. Newkirk, G. E. Davis, R. E. Harman

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W1492396017

FWCI: 2.632

Cites: 2

Cited by: 18

Related to: 10