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Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents

Year: 2009

Type: article

Abstract: The ethanolic extract of the trunk bark of Amburana cearensis (EEA) was examined for its oral (p.o.) analgesic activity at the doses of 100, 200 and 400 mg/kg body weight. In the acetic acid-induced writhing test, the EEA (200 and 400 mg/kg, p.o.) reduced the number of writhing by 33.4% and 40.7%, respectively. Additionally, EEA (100, 200 and 400 mg/kg, p.o.) decreased by 77.5%, 79.7 and 91.3%, respectively, the paw liking time in the second phase of the formalin test. Therefore, EEA showed a dose-dependent analgesic effect in formalin test and was effective in reducing writhing in mice.

Source: Revista Brasileira de Farmacognosia

DOI: 10.1590/s0102-695x2009000500004