Coformer Selection: an Important Tool in Cocrystal Formation
Year: 2014
Type: article
Abstract: Cocrystals are multicomponent system in which one component is Active Pharmaceutical Ingredient (API) and another is called coformer. So coformer selection is one of the main challenge in cocrystal development which is compatible with API. A general approach to coformer selection is by “tactless” cocrystal screening, whereby a predetermined library of pharmaceutically acceptable/approved compounds is used to attempt cocrystallization. In cocrystal development one of the approach of coformer selection is based on trial and error. Other approaches are supramolecular synthon approach which utilizes Cambridge Structural Database (CSD ) to effectively prioritize coformers for crystal form screening, Hansen solubility parameter and knowledge of hydrogen bonding between coformer and API. In this review, all the parameters are explain and correlate with each other and with cocrystal formation Keywords: Cocrystal, Coformer, Supramolecular synthon, Cambridge structural database, Hansen solubility parameter.
Authors: Sulbha R. Fukte, Milind Wagh, Shilpi Rawat
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W1507640326