Polyvinyl Alcohol - Melamine Formaldehyde Films and Coatings With Silver Nano Particles as Wound Dressings in Diabetic Foot Disease
Year: 2015
Type: article
Abstract: Globally there is a large population of people suffering with diabetes. A large percentage of these patients develop foot ulcers at some point that heals very slowly and can worsen very rapidly. The use of silver nanoparticles in silver release dressings and in management of infected wounds is important, as several pathogenic bacteria have developed resistance against various antibiotics over time. Such dressings vary in technological nature of their silver content and release .Use of silver dressings in recent times has a considerable challenge of lacking cost effectiveness. In-vitro susceptibility of microorganisms causing foot ulcers to a silver nanocomposite of Polyvinyl alcohol ( PVA) and Melamine formaldehyde (MFR) resin both as films and coatings is being reported. AgNP solution was prepared by colloidal route and characterised. MFR was prepared and reacted with PVA and AgNP solution to obtain PVA-MFR composite and PVA-MFR-Ag composite. The antimicrobial composites were casted into films, also soaked into polyvinyl foam, and coated on Whatman paper. Antimicrobial efficacy of such prepared dressing materials was tested. They are stable and do not lose their antimicrobial activity with time. Tissues from the wounds of five diabetic patients with deep foot infections were collected to isolate and identify the microorganism responsible for causing foot ulcers in diabetic patients. Their sensitivity towards various antibiotics was studied. Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa and Enterobacter cloacae species isolated from wound samples, though were found resistant to many antibiotics are sensitive to PVA-MFR-Ag films. These silver composites can be cost effective for the reason that efficacy of nanosilver is superimposed on antimicrobial activity of cheaper PVA-MFR composite. Thus, AgNP immobilised on antimicrobial PVA-MFR, could probably be a promising wound dressing in diabetic foot disease management.
Source: European Chemical Bulletin
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1519737553