Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry
Year: 2015
Type: article
Abstract: Optical coherence tomography (OCT) oximetry explores the possibility to measure retinal hemoglobin oxygen saturation level (sO2). We investigated the accuracy of OCT retinal oximetry using Monte Carlo simulation in a commonly used four-layer retinal model. After we determined the appropriate number of simulated photon packets, we studied the effects of blood vessel diameter, signal sampling position, physiological sO2 level, and the blood packing factor on the accuracy of sO2 estimation in OCT retinal oximetry. The simulation results showed that a packing factor between 0.2 and 0.4 yields a reasonably accurate estimation of sO2 within a 5% error tolerance, which is independent of vessel diameter and sampling position, when visible-light illumination is used in OCT. We further explored the optimal optical spectral range for OCT retinal oximetry. The simulation results suggest that visible spectral range around 560 nm is better suited than near-infrared spectral range around 800 nm for OCT oximetry to warrant accurate measurements.
Institution: Northwestern University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic Retinopathy, G2504027692, G2546218206, Multimodal Retinal Functional Imaging for Diabetic Retinopathy, Collaborative Research in Biophotonics: Towards high-resolution, label-free molecular imaging in deep tissue via stimulated Raman excitation and ultrasound detection, IDBR: TYPE A: Directly Integratable Photoacoustic Microscopy with Established Optical Microscopy for Comprehensive Sub-cellular Biological Imaging, G4439475616, CAREER: Functional imaging to prevent blindness, G7873484468
OpenAlex ID: W1536522980