El fibrinógeno como factor de riesgo de enfermedad aterotrombótica
Year: 2009
Type: article
Abstract: Both endothelial dsyfunction and inflammation play a crucial role from early stages of atherosclerosis up to the triggering of acute coronary syndromes, in which fibrinogen has shown to participate actively. Besides, elevated fibrinogen is related with thrombosis and it has proven to be an independent cardiovascular risk factor. Nowadays elevated level fibrinogen together with C-reactive protein, lipoprotein (a) and homocysteine are considered as emerging cardiovascular risk factors. The present work reviews briefly the association between high fibrinogen levels and cardiovascular trombosis risk, including a look on the structure and biological functions of fibrinogen. Also, modificable and non-modificable factors leading to elevated plasma fibrinogen are presented and the relevance of the control of those modificable for the prevention and management of atherothrombotic diseases is discussed. Data from observational epidemiological and randomized clinical studies support that elevated plasma fibrinogen is an independent cardiovascular risk factor, associated with conventional risk factors and genetic polymorphisms. It is concluded that lifestyle changes and pharmacological treatment can help control or reduce high plasma fibrinogen and that determination and assessing of fibrinogen levels in high risk individuals is encouraged within the prevention of cardiovascular events. Likewise, a larger number of studies are necessary for a better understanding of the role of fibrinogen in the increase of cardiovascular thrombotic risk.
Author: Fernández Travieso, Julio César
Institution: Centro Nacional de Investigaciones Científicas
Language: Spanish
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1542055898