Work

Synthesis and analgesic activity of novel heterocycles, (1)benzothiopyrano(3,4-b)pyrrole derivatives.

Year: 1989

Type: article

Abstract: In order to develop analgesic compounds possessing a sulfur atom in the alicyclic ring, novel cis-fused heterocycles, [1]benzothiopyrano[3,4-b]pyrrole derivatives (II) were synthesized via a unique cyclization reaction starting from 4-(4-methoxyphenylthio)-2-butanone (1) or 6-methoxy-3,4-dihydro-2H-1-benzothiopyran-4-one (7). The analgesic effects of benzothiopyranopyrroles (16, 18) were measured by means of the writhing test. The phenolic derivative 18 completely inhibited the appearance of writhing at the dose of 50 mg/kg, but the methoxy derivative 16 had no analgesic effect.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.37.1282

Authors: Mikio HORI, Tadashi KATAOKA, Hiroshi SHIMIZU, Eiji IMAI, Noriyuki IWATA, Norihiro KAWAMURA, Masayasu KURONO, Kazumasa NAKANO, Masaru KIDO

Institution: Otsuka (Japan)

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1565709366

FWCI: 0.478

Cites:

Cited by: 7

Related to: 10