Year: 1973
Type: article
Abstract: The undecapeptide amide, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, corresponding to the entire amino acid sequence of substance P, a bovine hypothalamic peptide, was synthesized by the conventional method. This and C-terminal tetra, penta, hexa, hepta and octapeptide amides were submitted for biological assays. Synthetic substance P caused considerable decrease in blood pressure and heart rate in anesthetized rat, but other shorter chain peptides were less active. When contractility on isolated guinea-pig ileum was examined, the heptapeptide amide exhibited much higher activity than synthetic substance P.
DOI: 10.1248/cpb.21.2500
Authors: HARUAKI YAJIMA, KOUKI KITAGAWA, TOMIRO SEGAWA
Institutions: Hiroshima University, Kyoto University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1590621789