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Диффузионно-транспортные свойства поликомплексных матричных систем, образованных Eudragit® EPO и Carbomer 940

Year: 2010

Type: article

Abstract: Interpolyelectrolyte complexes (IPECs) between Eudragit® EPO (EPO) and Carbomer 940 (C940) were obtained and investigated with a view to their use in peroral controlled drug delivery systems. Due to the structural features of IPECs, their swelling profiles are completely different from those of individual (co)polymers and related physical mixtures. The structural and compositional microenvironmental changes in the IPEC matrix during swelling at various pH were studied by FTIR spectroscopy, MT - DSC method, and elementary analysis. A mechanism responsible for the release of a model drug (ibuprofen) from the polycomplex matrix is established.

Source: Химико-фармацевтический журнал

DOI: 10.30906/0023-1134-2010-44-3-38-41

Authors: Р. И. Мустафин, Tatyana V. Kabanova, Е. Р. Жданова, А. В. Буховец, В. Р. Гарипова, Ш. Ф. Насибуллин, В. А. Кеменова

Institutions: Kazan State Medical University, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Language: Russian

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1593663723

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