Work

Pathogenesis of Chronic Chagasic Myocarditis

Year: 2013

Type: book-chapter

Abstract: 10 -30 years after the original acute infection, will develop cardiac, digestive or mixed form of the disease, characterized by the appearance of megavicera (dilated cardiomyopathy, megaesophagus and/or megacolon).It poses a substantial public health burden due to high morbidity and mortality [3,7,9].CCC is manifested by a chronic, diffuse, progressive fibrosing myocarditis that involves not only the working myocardium but also the atrioventricular (AV) conduction system, autonomic nervous system and microcirculation [10 -12].This leads to cardiomegaly, cardiac failure, arrhythmias, thromboembolism, and death [11].Colon and esophagus are also commonly affected by Chagas' disease, being megacolon with constipation and megaesofagus with achalasia also features of the disease [7].

Source: InTech eBooks

DOI: 10.5772/55387

Authors: Julin Gonzlez, Francisco Azzato, Giusepe Ambrosio, Jos Milei

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Università degli Studi di Perugia, Secretaría de Ciencia y Técnica, Universidad de Buenos Aires

Awards: G2439265903, G8080363669