Congenital Hypothyroidism: Effects on Linear Growth, Catch- Up Growth, GH-IGF-I Axis and Bones
Year: 2013
Type: book-chapter
Abstract: Triiodothyronine (T3) is a primary determinant of normal postnatal somatic and 9 skeletal development, and an important regulator of bone and mineral metabolism in hu‐ 10 man [1, 2]. Before puberty, thyroid hormone appears to be a major prerequisite for normal 11 maturation of bone [3]. Untreated childhood hypothyroidism results in a profound 12 retardation and a delayed skeletal maturation. In severe cases, linear is almost com‐ 13 pletely halted. When treatment occurs, often resumes at a rate faster and beyond the 14 normal rate for age [3, 4]. This phase of accelerated constitutes the catch-up growth 15 phenomenon. This may be complete or incomplete depending upon many factors including 16 the age at presentation, the severity of hypothyroidism and its duration, the age at diagno‐ 17 sis, and the genetic target height. 18
Source: InTech eBooks
DOI: 10.5772/53317
Authors: Ashraf T., Vincenzo De, El Said M.A. Bedair
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1600166609