Work

Lactate: A key metabolite in the intercellular metabolic interplay.

Year: 2002

Type: article

Abstract: Most physicians involved in intensive care consider lactate solely as a deleterious metabolite, responsible for high morbidity and bad prognosis in severe patients. For the physiologist, however, lactate is a key metabolite, alternatively produced or consumed. Many studies in the literature have infused animals or humans with exogenous lactate, demonstrating its safety and usefulness, but the bad reputation of lactate is still widespread. The metabolic meaning of glucose–lactate cycling exceeds its initial role described by Cori and Cori. According to recent works concerning lactate, it can be predicted that a new role as a therapeutic agent will arise for this metabolite.

Source: Critical Care

DOI: 10.1186/cc1509

Authors: Xavier M Leverve, Iqbal Mustafa

Institutions: Inserm, Université Joseph Fourier, Laboratory of Fundamental and Applied Bioenergetics

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190