(Artigo 6 publicado v.28 n.2) Influência do tratamento com metformina sobre a tolerância à glicose induzida por corticosteróides em ratos Wistar
Year: 2006
Type: article
Abstract: This work evaluated the effect of the corticosteroid administration on glucose intolerance state induced by dexamethasone (0.1 mg kg-1, s.c., 4 days). The experimental model was characterized through blood and urine glucose levels determination, 24 hour urinary volume, food and water intake. The rats were treated with chlorpropamide (100 mg kg-1), metformin (300 mg kg-1) or pioglitazone (10 mg kg-1) during 4 days. The effect of adrenalectomy or the drugs treatment effectiveness on hyperglycemia state were evaluated during intravenous GTT. Metformin treatment restored the altered hyperglycemia observed in this experimental model. Results suggest that dexamethasone promotes a hyperglycemia state through a synergic effect on endogenous corticosteroids, and that metformin treatment restores these altered responses. Indeed, the dexamethasone induced insulin resistance in humans, promoting hyperglycemia, which should be avoid by the prophylactic administration of metformin
Source: Acta Scientiarum Health Sciences
Institution: Universidade Estadual de Maringá
Language: Portuguese
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1663780209