Year: 2015
Type: article
Abstract: The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and autoimmune disease.
Source: The Journal of Cell Biology
Authors: Barry J. Thompson, Erik Sahai
Institution: The Francis Crick Institute
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
Funder: Francis Crick Institute
Awards: G1240145365, G3102812662
OpenAlex ID: W1664030242