Electrochemical Studies of Buzepide Methiodide and their Analytical Applications
Year: 2008
Type: article
Abstract: The electrochemical behavior of buzepide methiodide (BZP) was investigated by cyclic, linear sweep and differential pulse voltammetric (DPV) techniques. The electrochemical studies were carried out on a glassy carbon electrode at room temperature. BZP showed a pair of quasireversible peaks. The effect of peak current and peak potential on scan rate, pH, concentration and different electrolytes was investigated. The oxidation and reduction currents were observed to be diffusion controlled between the scan rates of 5 to 500 mV s-1 and 5 to 50 mV s-1, respectively. The oxidation and reduction currents of BZP were observed to be pH dependent. Bulk electrolysis was performed to obtain the oxidized product and the same was identified by IR spectroscopy. Probable mechanism was proposed for redox reaction of BZP. Considering the sensitivity, anodic peak was selected for analytical application. Highly resolved diffusion controlled oxidation peak was noticed in Britton-Robinson (BR) buffer of pH 2.5. An analytical method with adequate precision and accuracy was developed for the determination of BZP with the detection limit of 1.13 x 10-6. A linear response of current-concentration was obtained in the range of 1.6 x 10-6 to 1.7 x 10-5 M for DPV with a correlation coefficient value of 0.9978. The proposed procedure was successfully applied to the determination of BZP in tablets.
Institution: Karnatak University
Language: English
Subfield: Electrochemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,670
OpenAlex ID: W166752710