Year: 2015
Type: article
Abstract: The effects of acute stress on the peripheral circadian system are not well understood in vivo. Here, we show that sub-acute stress caused by restraint or social defeat potently altered clock gene expression in the peripheral tissues of mice. In these peripheral tissues, as well as the hippocampus and cortex, stressful stimuli induced time-of-day-dependent phase-advances or -delays in rhythmic clock gene expression patterns; however, such changes were not observed in the suprachiasmatic nucleus, i.e. the central circadian clock. Moreover, several days of stress exposure at the beginning of the light period abolished circadian oscillations and caused internal desynchronisation of peripheral clocks. Stress-induced changes in circadian rhythmicity showed habituation and disappeared with long-term exposure to repeated stress. These findings suggest that sub-acute physical/psychological stress potently entrains peripheral clocks and causes transient dysregulation of circadian clocks in vivo.
Source: Scientific Reports
DOI: 10.1038/srep11417
Institution: Waseda University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Effect of night time shift work on the circadian clock system, Gut Microbiota-Derived Short Chain Fatty Acids Accelerate Food-Induced Circadian Clock Entrainment in Mouse Peripheral Tissue, G4206246677, Basic and applied studies of chrononutrition based on development of functional foods and nutrients, Anti-obesity approach by weekly rhythm of nutrition and exercise
OpenAlex ID: W1837114591