Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome: RIC-HSCT for MF/SS
Year: 2014
Type: article
Abstract: Advanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954 days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and 'down-staging' effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS.
Source: Hematological Oncology
DOI: 10.1002/hon.2162
Institutions: Hokkaido University, Hokkaido University Hospital
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: A novel mechanism of posttransplant female infertiliy, Innate immune signals in allogeneic hematopoietic stem cell transplantation, Mechanisms of disruption of homeostasis in GVHD, Reconstitution of mononuclear phagocyte system following allogeneic hematopoietic stem cell transplantation, Role of NKG2D ligands in prediction of response to cancer antibody therapy, Identification of biological characterization and predictive factors for therapeutic effect in primary diffuse large B-cell lymphoma of the central nervous system
OpenAlex ID: W1852839769