Year: 1988
Type: article
Abstract: An epizootic of Staphylococcus infection causing abscesses was encountered in a small-scale breeding colony of nude mice of BALB/c background. The incidence of abscess was sporadic and mostly nude (nu/nu) mice aged over 3 months were affected. Staphylococcus aureus was isolated from the face, oral cavity, and feces of almost all nu/nu and heterozygous (nu/+) mice in the colony. After a prolonged time period, up to 10 to 14 months of age, almost all the S. aureus-carrying nu/nu mice produced abscesses and eventually died. Athymicity of the host seemed to be a prerequisite for the abscess formation since nu/+ mice were spared from the lesions. Also, transfer of immunocompetent spleen cells cured the abscesses of the affected nude mice.
Source: EXPERIMENTAL ANIMALS
Authors: Reiko SANO, Shigeki YAMAMOTO, Hiroshi KAMIMURA, Masanobu KIMURA, Katsumoto UEDA, Akira SHIMIZU, Junichi KAWANO, Shige KIMURA
Language: Japanese
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W186760449