Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy
Year: 2015
Type: article
Abstract: We achieved human retinal imaging using visible-light optical coherence tomography (vis-OCT) guided by an integrated scanning laser ophthalmoscopy (SLO). We adapted a spectral domain OCT configuration and used a supercontinuum laser as the illumating source. The center wavelength was 564 nm and the bandwidth was 115 nm, which provided a 0.97 µm axial resolution measured in air. We characterized the sensitivity to be 86 dB with 226 µW incidence power on the pupil. We also integrated an SLO that shared the same optical path of the vis-OCT sample arm for alignment purposes. We demonstrated the retinal imaging from both systems centered at the fovea and optic nerve head with 20° × 20° and 10° × 10° field of view. We observed similar anatomical structures in vis-OCT and NIR-OCT. The contrast appeared different from vis-OCT to NIR-OCT, including slightly weaker signal from intra-retinal layers, and increased visibility and contrast of anatomical layers in the outer retina.
Source: Biomedical Optics Express
DOI: 10.1364/boe.6.003701
Authors: Ji Yi, Siyu Chen, Xiao Shu, Amani A. Fawzi, Hao F. Zhang
Institution: Northwestern University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,913
Awards: G1268790672, G1972581785, G2674981899, Multimodal Retinal Functional Imaging for Diabetic Retinopathy, Collaborative Research in Biophotonics: Towards high-resolution, label-free molecular imaging in deep tissue via stimulated Raman excitation and ultrasound detection, IDBR: TYPE A: Directly Integratable Photoacoustic Microscopy with Established Optical Microscopy for Comprehensive Sub-cellular Biological Imaging, G4439475616, CAREER: Functional imaging to prevent blindness, G6393072127, G9000115067, G949422507
OpenAlex ID: W1884342291