Year: 2015
Type: editorial
Abstract: The Greek philosopher Plato emphasized the importance of moderating personal desires for the functioning of society. The virtue of moderation is also critical for the live-long function of hematopoietic stem cells (HSC), the origin of all blood cells. To prevent undue activation, which can deplete HSC and increase the risk of blood cancer, HSC need to restrain signaling by phosphoinositide 3-kinases (PI3K)- a pivotal pathway whose hyperactivation contributes to many diseases [1]. Yet, the precise mechanisms limiting PI3K-signaling within HSC remain ill understood. We recently presented evidence that they include non-canonical PI3K-regulation by the little-studied enzyme inositoltrisphosphate 3-kinase B (IP3 3-kinase B/Itpkb) in HSC [2]. Itpkb-/- mice died with HSC/hematopoietic-progenitor-cell (HPC) depletion
Source: Oncotarget
Authors: Stephanie Rigaud, Karsten Sauer
Institution: Scripps Research Institute
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1900186605