Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters
Year: 1984
Type: article
Abstract: Cobra venom factor, an agent commonly used to deplete complement, lowered the resistance of hamsters to infection with Treponema pallidum subsp. endemicum , as shown by a more rapid development of cutaneous lesions in infected animals treated with cobra venom factor than in infected, untreated animals. Cobra venom factor also abrogated the passive transfer of resistance by injection of serum from syphilitic immune hamsters. These results indicate that complement influences the pathogenesis of treponemal infection.
Source: Infection and Immunity
Authors: A A Azadegan, D R Tabor, R F Schell, J L LeFrock
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1908699218