MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer
Year: 2015
Type: article
Abstract: // Xinyang Liu 1, * , Xiaoxiao Ge 1, * , Zhe Zhang 2 , Xiaowei Zhang 2 , Jinjia Chang 1 , Zheng Wu 1 , Wenbo Tang 1 , Lu Gan 1 , Menghong Sun 3 , Jin Li 4 1 Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China 2 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China 3 Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China 4 Department of Medical Oncology, Shanghai Tianyou Hospital of Tongji University, Shanghai, 200032, P.R. China * These authors have contributed equally to this work Correspondence to: Jin Li, e-mail: [email protected] Keywords: gastric cancer, miR-940, ZNF24, metastasis, epithelial-mesenchymal transition Received: March 23, 2015 Accepted: June 15, 2015 Published: June 27, 2015 ABSTRACT Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.
Source: Oncotarget
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1908973472